Mianserin and Mania

Mianserin and agranulocytosis.

An alcoholic woman who was admitted to hospital for detoxification was prescribed thyroxine because of hypothyroidism and mianserin to alleviate severe depression. After several weeks' treatment she became unwell and was readmitted to hospital. Haematological examination indicated agranulocytosis. Further extensive investigations elicited no cause for this other than the mianserin, since no suc...

Hepatic injury caused by mianserin.

Ventricular Fibrillation Caused by Mianserin Poisoning

Case: A 56-year-old man who revived after ventricular fibrillation was transferred to the emergency center at Kansai Medical University. The blood examination, computed tomography, and cardiac echocardiography at the time admission could not detect the cause of ventricular fibrillation. However, high-performance liquid chromatography revealed mianserin and aripiprazole in his serum. The concent...

The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine

A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions.

Citalopram and mania.

Treatment-emergent mania has been reported with various selective serotonin reuptake inhibitors (SSRIs) (Diler and Avci, 1999; Grubbs, 1997). We report four cases of citalopram-induced mania in children. Case 1. A 6-year-old boy with a family history of obsessivecompulsive disorder (OCD) was diagnosed with severe depression without psychotic symptoms. He developed mania without psychotic sympto...